Mechanism of bimolecular (SN2) nucleophilic substitution [Mechanism & Kinetics] An S
N2 reaction proceeds with complete stereo chemical inversion.
S
N2 reaction decreases with stearic hinderance and increases by presence of nonprotic solvent for example DMF and DMSO. S
N2 reaction decreases in the presence of protic solvent like CH
3OH, C
2H
5OH, HF etc.
As the size of alkyl group increases than chemical reactivity towards S
N2 decreases.
As the size of alkyl group increases sterichindrance comes into play so reactivity decreases.
